ISSUE

Volume-IX

, Issue-I

(WINTER 2024)

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01 - A Comprehensive Review on Implementation of Quality by Design in Varied Pharmace

http://dx.doi.org/10.31703/gpsr.2024(IX-I).01
10.31703/gpsr.2024(IX-I).01      Published : Mar 2024

Abstract

    This review article investigates how Quality by Design (QbD) ideas are used in different pharmaceutical development processes, such as the creation of analytical methods, formulation optimization, and nanoparticle production. In order to improve product quality, reliability, and regulatory compliance, it covers a variety of studies that use QbD approaches. Critical quality attributes and process v... Details

    Quality by Design, formulation Development, Design Space, Pharmaceuticals.

    (1) Aqsa Qaisar
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Maryam Sikandar
    Graduate,Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Rehan Rustam
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
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02 - Applications and Challenges of CRISPER/Cas-9 System in Cancer Therapy

http://dx.doi.org/10.31703/gpsr.2024(IX-I).02
10.31703/gpsr.2024(IX-I).02      Published : Mar 2024

Abstract

    This review article is aimed at providing an outline of the present information base available on the applications of CRISPR/Cas9 in cancer therapy and the challenges raised by its implementation. We will first explain the mechanism of action and other key components pertaining to the functioning of CRISPR/Cas9 technology. Further, we will provide case studies that have had some success in pre-cli... Details

    Recombinant DNA Technology, CRISPER/Cas-9, Applications, Challenges, Genome, Genome Engineering.

    (1) Ahmad Jalal Masood
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Ejaz Ahmed
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Rimsha Iftikhar
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
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03 - Genetic Polymorphism and Its Impact on Atorvastatin Efficacy: Personalizing Hype

http://dx.doi.org/10.31703/gpsr.2024(IX-I).03
10.31703/gpsr.2024(IX-I).03      Published : Mar 2024

Abstract

    Hyperlipidemia is a main risk factor for coronary heart disease, which is commonly treated with statins, especially atorvastatin. However, the efficacy and harmful effects vary from person to person. Nearly 50% discontinue treatment within one year, mainly because of intolerance to statins associated with musculoskeletal symptoms. The presence of genetic polymorphisms in various genes greatly affe... Details

    Genetic Polymorphism, Statin, Atorvastatin, Hyperlipidemia, LDL, HDL

    (1) Huma Sajjad
    ASHP IPPRP Resident Pharmacist, Shifa International Hospital (SIH), Islamabad, Pakistan.
    (2) Syed Muhammad Talha
    ASHP IPPRP Resident Pharmacist, Shifa International Hospital (SIH), Islamabad, Pakistan.
    (3) Syed Qurat ul Ain Ali
    Staff Pharmacist, Shifa International Hospital (SIH), Islamabad, Pakistan.
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04 - pH Responsive Drug Delivery Systems for Cancer Treatment

http://dx.doi.org/10.31703/gpsr.2024(IX-I).04
10.31703/gpsr.2024(IX-I).04      Published : Mar 2024

Abstract

    pH-responsive Polymer-Based Systems like polymeric micelles, hydrogels, and lipid-based technologies can assist in cancer treatment where drugs are undergoing release only at certain regions within a tumor implant hence augmenting their delivery efficiency. pH-Responsive polymers and lipids can change their structures in response to the pH gradient of solid tumors; this permits stepwise medication... Details

    pH-responsive Polymers, Cancer Therapy, Polymeric Micelles, Hydrogels, Lipid-Based Systems, Drug Delivery Systems, Tumor Micro Environment (Tme), pH-Sensitive Liposomes, Inorganic Nanoparticles, Quant

    (1) Maida Noor
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (2) Muhammad Saad Ali
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
    (3) Hafiza Arooba Shakeel
    Graduate, Department of Pharmacy, Quaid-i-Azam University, Islamabad, Pakistan.
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