Antimicrobial therapy failure against wound infections and arise of extended resistance highly encourages the discovery of novel mechanisms to overcome underlying issues. Major causative agent for causing wound infection is "Staphylococcus aureus" and recent medications lack antibacterial action,mucoadhesion and patient compliance. Thiolation proves itself as a novel technique for treatment of wound infections via topical application. Thiomers possesses features such as higher porosity, bio degradation, and swelling index. Thiolated products are resistant to the harsh environmental changes. Similarly, with the advancements in drug delivery, various smart drug delivery techniques lead to enhancement in drug delivery. Nano particles allow the drugs to penetrate the cells by diffusion or energy dependent process and degrade themselves at specified siteof action by either attachment of recognition ligands or responsive stimuli. Overall, the Thiolated polymers and Nano medicines depicted potential to cure wounds with increased severity meeting the required features of an ideal wound dressing.