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  <journal-id journal-id-type="short-title">gpsr</journal-id>
  <journal-id journal-id-type="doi">10.31703/gpsr</journal-id>
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    <journal-title>Global Pharmaceutical Sciences Review</journal-title>
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  <issn publication-format="print">2788-5569</issn>
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<article-meta>
  <article-id pub-id-type="publisher-id">394306</article-id>
  <article-id pub-id-type="doi">10.31703/gpsr.2023(VIII-II).04</article-id>
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  <title-group>
    <article-title xml:lang="en">Frequency of Cardiac Arrhythmias Detection on 24 Hours Holter Monitoring</article-title>
  </title-group>
<contrib-group>
  <contrib contrib-type="author" seq="1" corresp="yes">
    <name>
      <surname>Hadi</surname>
      <given-names>Noorul</given-names>
    </name>
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    <name>
      <surname>Asfandiyar</surname>
      <given-names>Asfandiyar</given-names>
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  <contrib contrib-type="author" seq="3">
    <name>
      <surname>Alam</surname>
      <given-names>Shafiq</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
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  <contrib contrib-type="author" seq="4">
    <name>
      <surname>Khan</surname>
      <given-names>Jehandad</given-names>
    </name>
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    <name>
      <surname>Raza</surname>
      <given-names>Sarmad</given-names>
    </name>
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  <contrib contrib-type="author" seq="6">
    <name>
      <surname>Shah</surname>
      <given-names>Ibrahim</given-names>
    </name>
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  <aff id="aff1">
    <label>1</label>
    <institution-wrap>
      <institution>Cardiology Unit, MTI Mardan Medical Complex, Mardan</institution>
    </institution-wrap>
    <named-content content-type="author-role">Assistant Professor</named-content>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff2">
    <label>2</label>
    <institution-wrap>
      <institution>Post Graduate Trainee, Cardiology Unit, MTI Mardan Medical Complex, Mardan</institution>
    </institution-wrap>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff3">
    <label>3</label>
    <institution-wrap>
      <institution>Gajju Khan Medical College, Swabi</institution>
    </institution-wrap>
    <named-content content-type="author-role">Associate Professor</named-content>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
</contrib-group>
<author-notes>
  <corresp id="cor1">Corresponding Author: Noorul Hadi, Assistant Professor, Cardiology Unit, MTI Mardan Medical Complex, Mardan, KP, Pakistan.</corresp>
<fn fn-type="COI-statement" id="fn-coi">
  <p>The authors declare that they have no conflicts of interest.</p>
</fn>
<fn fn-type="ethics-statement" id="fn-ethics">
  <p>This study did not require formal ethics approval.</p>
</fn>
<fn fn-type="data-availability-statement" id="fn-data">
  <p>Data sharing is not applicable to this article.</p>
</fn>
</author-notes>
<pub-date pub-type="epub" date-type="pub" publication-format="electronic">
  <day>30</day>
  <month>06</month>
  <year>2023</year>
</pub-date>
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  <month>06</month>
  <year>2023</year>
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<pub-date date-type="pub" publication-format="print">
  <day>09</day>
  <month>05</month>
  <year>2023</year>
</pub-date>
  <volume>8</volume>
  <issue>2</issue>
  <season>Spring</season>
  <fpage>18</fpage>
  <lpage>22</lpage>
  <history>
    <date date-type="accepted">
      <day>09</day>
      <month>05</month>
      <year>2023</year>
    </date>
  </history>
<funding-group>
  <funding-statement>
<p>The authors received no specific funding for this work.</p>
  </funding-statement>
</funding-group>
<permissions>
  <copyright-year>2023</copyright-year>
  <copyright-holder>Humanity Publications</copyright-holder>
  <license license-type="open-access" xml:lang="en" xlink:href="https://creativecommons.org/licenses/by/4.0/">
    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License.</license-p>
  </license>
</permissions>
<self-uri content-type="text/html" xlink:href="https://gpsrjournal.com/article/frequency-of-cardiac-arrhythmias-detection-on-24-hours-holter-monitoring"/>
<self-uri content-type="pdf" xlink:href="https://gpsrjournal.com/pdf/gpsr/FhkNjYv273.pdf"/>
<supplementary-material id="suppl-pdf" content-type="pdf" xlink:href="https://gpsrjournal.com/pdf/gpsr/FhkNjYv273.pdf">
  <label>PDF</label>
  <caption>
    <title>Full Text PDF</title>
  </caption>
</supplementary-material>
  <abstract>
    <p>To determine the clinical outcomes and assess the diagnostic yield of Holter monitoring and its potential use in diagnosing and managing abnormal rhythms, along with identifying patterns or trends in the prevalence of different arrhythmias, which could modify and design future research and clinical practice. It was a descriptive cross sectional study carried out at MMC Mardan on around 1000 patients, from June 2017 to December 2022. Three trained Cardiologists having more than 03 years of experience reviewed the 24-hour monitor data through the system. Among these 1000 patients, 31% had at least one arrhythmia detected on 24-hour Holter monitoring. The most common arrhythmias detected were premature ventricular contractions (54%), followed by Atrial fibrillation (18%) and supraventricular tachycardia (15%) while 2.3% had first-degree AV block, 4.5% had second-degree AV block, and 0.8% had third-degree AV block. In conclusion, our study showed that Holter monitoring for 24 hours is a useful tool for detecting a range of cardiac arrhythmias, with premature ventricular contractions being on the top, with some forms of AV block also being detected in a small group of patients, having first-degree AV block being the most common type.</p>
  </abstract>
<kwd-group kwd-group-type="author-keywords">
  <kwd>Cardiac Arrhythmias</kwd>
  <kwd>Holter Monitoring</kwd>
  <kwd>Cardiology</kwd>
  <kwd>Mardan Medical Complex</kwd>
  <kwd>AV Block</kwd>
  <kwd>Ventricular Contractions</kwd>
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</front>
<body>
<sec id="sec-1">
  <title>Abstrict</title>
<p>To determine the clinical outcomes and assess the diagnostic yield of Holter monitoring and its potential use in diagnosing and managing abnormal rhythms, along with identifying patterns or trends in the prevalence of different arrhythmias, which could modify and design future research and clinical practice. It was a descriptive cross-sectional study carried out at MMC Mardan on around 1000 patients, from June 2017 to December 2022. Three trained Cardiologists having more than 03 years of experience reviewed the 24-hour monitor data through the system. Among these 1000 patients, 31% had at least one arrhythmia detected on 24-hour Holter monitoring. The most common arrhythmias detected were premature ventricular contractions (54%), followed by Atrial fibrillation (18%) and supraventricular tachycardia (15%) while 2.3% had first-degree AV block, 4.5% had second-degree AV block, and 0.8% had third-degree AV block. In conclusion, our study showed that Holter monitoring for 24 hours is a useful tool for detecting a range of cardiac arrhythmias, with premature ventricular contractions being on the top, with some forms of AV block also being detected in a small group of patients, having first-degree AV block being the most common type.</p>
</sec>
<sec id="sec-2">
  <title>Introduction</title>
<p>A Holter monitor is used for cardiac monitoring that records the heart&apos;s electrical activity over a specific period of time, typically for 24 to 48 hours (Barrett et al., 2014). The device used is a portable electrocardiogram (ECG) machine attached to the patient&apos;s chest using electrodes (Bansal &amp; Joshi, 2018), which are connected to a small recording device that the patient carries with them throughout the monitoring period and is then decoded with computer-based software&apos;s. (Fensli et al., 2005)</p><p>Holter monitoring is used to analyze the heart&apos;s rate and rhythm during routine activities, and it can help to detect abnormal heartbeats or arrhythmias that a short strip of ECG usually doesn’t pick (Lobodzinski &amp; Laks, 2012). A Holter monitor is also very helpful in determining disorders such as palpitations, fainting, and chest pain and also in assessing the effectiveness of various medications or treatments. (Linzer, 1997)</p><p>A study published in the American College of Cardiology Journal found that Holter monitoring was helpful in identifying significant arrhythmias in 10.9% of people who had previously undergone a standard ECG, which turned out to be normal yet they experienced symptoms (Al-Khatib et al., 2018). This indicates that this can be a valuable tool for recognizing arrhythmias that were not detected using 12 lead standard ECGs. Additionally, studies also found that it was also effective in identifying asymptomatic arrhythmias in patients who had previously suffered a stroke or transient ischemic attack (Ziegler et al., 2012) (Sejr et al., 2017).</p><p>Studies done in the past have focused on target patient populations or types of arrhythmias, like those with palpitations or who have suffered a stroke or transient ischemic attack. However, there is a lack of comprehensive studies that examine the overall frequency and distribution of different types of arrhythmias detected on 24-hour Holter monitoring in diverse patient populations. That&apos;s why this study will help us in providing valuable information for clinicians in terms of understanding the diagnostic yield of Holter monitoring and its potential use in diagnosing and managing abnormal rhythms. Additionally, this study will help in identifying patterns or trends in the prevalence of different arrhythmias, which could modify and design future research and clinical practice.</p>
</sec>
<sec id="sec-3">
  <title>Material and Methods</title>
<p>It was a descriptive cross-sectional study carried out at Medical teaching institution, Mardan Medical Complex. Approval was granted by the Ethical Committee of the hospital. Around 1000 patients were reviewed at the Cardiac Diagnostic Centre of Cardiology Department MMC Mardan, from June 2017 to December 2022. A structured Performa was made according to the design of our study. Three trained Cardiologists having more than 03 years of experience reviewed the 24-hour monitor data through the system. All variables were documented on the questionnaire first and then entered into the Excel sheet. SPSS Version 22 was used to import the data from an Excel file. Frequencies and prevalence of cardiac arrhythmias were calculated.</p>
</sec>
<sec id="sec-4">
  <title>Results</title>
<p>About 1000 patients were reviewed. 31% had at least one arrhythmia detected on 24 hours of Holter monitoring. The most common arrhythmias detected were premature ventricular contractions (54%), followed by Atrial fibrillation (18%) and supraventricular tachycardia (15%).2.3% had first-degree AV block, 4.5% had second-degree AV block, and 0.8% had third-degree AV block.</p><p><bold>Table </bold></p><table-wrap id="table1"><label>Table 1</label><caption><title>Table 1</title></caption><table><tbody><tr><td valign="top"> <p><bold>Arrhythmias</bold></p> </td><td> <p><bold>Frequency</bold></p> </td><td> <p><bold>Percentage</bold></p> </td></tr><tr><td> <p>PVCs</p> </td><td> <p>72</p> </td><td> <p>54%</p> </td></tr><tr><td> <p>AF</p> </td><td> <p>24</p> </td><td> <p>18%</p> </td></tr><tr><td> <p>SVT</p> </td><td> <p>20</p> </td><td> <p>15%</p> </td></tr><tr><td> <p>First-degree AV Block</p> </td><td> <p>3</p> </td><td> <p>2.3%</p> </td></tr><tr><td> <p>Second-degree AV Block</p> </td><td> <p>6</p> </td><td> <p>4.5%</p> </td></tr><tr><td> <p>3<sup>rd</sup> degree AV
  Block</p> </td><td> <p>1</p> </td><td> <p>0.8%</p> </td></tr></tbody></table></table-wrap>
</sec>
<sec id="sec-5">
  <title>Discussion</title>
<p>The findings of our study suggested that 24-hour Holter monitoring can be an effective tool for detecting a range of cardiac arrhythmias in patients, based on the fact that arrhythmias were detected in 31% of the patients being reviewed who underwent the test. This is consistent with previous research that has reported prevalence rates ranging from 13% to 46% depending on the population being studied and the specific type of arrhythmia being evaluated (Gibson &amp; Heitzman, 1984) (Priori et al., 2013).</p><p>These findings were also consistent with previous studies, which revealed that premature ventricular contractions were the most common rate ranging from 1.3% to 5.5% depending on the population being studied and the specific type of AV block being evaluated. The most common type of AV block detected in our study was first-degree, followed by second-degree and complete heart block. While the clinical significance of first-degree AV block is often considered to be minimal, second-degree and complete heart blocks may require further evaluation and management (Kusumoto et al., 2019) (Watanabe et al., 2014) (Solomon et al., 2016).</p><p>In addition to the prevalence of arrhythmias found on 24-hour Holter monitoring, the clinical consequences of these results must be considered. Using Holter monitoring to detect arrhythmias can provide useful insights into the underlying heart problems and suggest proper therapeutic methods. For example, the detection of severe arrhythmias like atrial fibrillation or supraventricular tachycardia might lead to the implementation of tailored treatments or interventions to lower the risk of consequences like stroke or hemodynamic instability.</p><p>Overall, this study helps to improve the present literature on the proper utilization of the Holter monitor as a diagnostic tool for cardiac arrhythmias. The findings suggest that it can be an effective source to identify a range of arrhythmias, including those that may not be detected on a standard electrocardiogram. However, further research is required to establish the significance and outcomes linked to these arrhythmias and to assess proper and suitable strategies for managing patients with these abnormalities.</p>
</sec>
<sec id="sec-6">
  <title>Conclusion</title>
<p>In conclusion, our study showed that Holter monitoring for 24 hours is a useful tool for detecting a range of cardiac arrhythmias, with premature ventricular contractions being on the top, with some forms of AV block also being detected in a small group of patients, having first-degree AV block being the most common type. Hence highlighting the importance of Holter monitoring in the diagnosis and management of cardiac arrhythmias, particularly in patients with symptoms such as palpitations or syncope.</p>
</sec>
</body>
<back>
<fn-group content-type="conflict-of-interest">
  <title>Conflict of Interest</title>
  <fn fn-type="conflict">
<p>The authors declare that they have no conflicts of interest.</p>
  </fn>
</fn-group>
<fn-group content-type="ethics-statement">
  <title>Ethics Statement</title>
  <fn fn-type="ethics">
<p>This study did not require formal ethics approval.</p>
  </fn>
</fn-group>
<fn-group content-type="data-availability">
  <title>Data Availability</title>
  <fn fn-type="data-availability-statement">
<p>Data sharing is not applicable to this article.</p>
  </fn>
</fn-group>
<app-group>
  <app id="app-suppl">
    <title>Supplementary Materials</title>
<supplementary-material id="suppl-pdf" content-type="pdf" xlink:href="https://gpsrjournal.com/pdf/gpsr/FhkNjYv273.pdf">
  <label>PDF</label>
  <caption>
    <title>Full Text PDF</title>
  </caption>
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