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  <journal-id journal-id-type="publisher-id">64</journal-id>
  <journal-id journal-id-type="short-title">gpsr</journal-id>
  <journal-id journal-id-type="doi">10.31703/gpsr</journal-id>
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    <journal-title>Global Pharmaceutical Sciences Review</journal-title>
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    <publisher-name>Humanity Publications</publisher-name>
    <publisher-loc>Pakistan</publisher-loc>
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<article-meta>
  <article-id pub-id-type="publisher-id">394266</article-id>
  <article-id pub-id-type="doi">10.31703/gpsr.2023(VIII-I).04</article-id>
  <article-id pub-id-type="other" specific-use="submission-id">4735</article-id>
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    <subj-group subj-group-type="heading">
      <subject>article</subject>
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  <title-group>
    <article-title xml:lang="en">Examination and Treatment of Malaria in Children Hospitalized to District Hospitals in Pakistan</article-title>
  </title-group>
<contrib-group>
  <contrib contrib-type="author" seq="1" corresp="yes">
    <name>
      <surname>Mohammed</surname>
      <given-names>Amir</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Conceptualization" vocab-term-identifier="https://credit.niso.org/contributor-roles/conceptualization/">Conceptualization</role>
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    <xref ref-type="aff" rid="aff1"/>
    <xref ref-type="corresp" rid="cor1"/>
  </contrib>
  <contrib contrib-type="author" seq="2">
    <name>
      <surname>Khan</surname>
      <given-names>Muhammad Qasim</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
    <xref ref-type="aff" rid="aff2"/>
  </contrib>
  <contrib contrib-type="author" seq="3">
    <name>
      <surname>Kiramatullah</surname>
      <given-names>Kiramatullah</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
    <xref ref-type="aff" rid="aff3"/>
  </contrib>
  <contrib contrib-type="author" seq="4">
    <name>
      <surname>Afridi</surname>
      <given-names>Haji Gul</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
    <xref ref-type="aff" rid="aff4"/>
  </contrib>
  <contrib contrib-type="author" seq="5">
    <name>
      <surname>Sijad-Ur-Rehman</surname>
      <given-names>Sijad-Ur-Rehman</given-names>
    </name>
    <role vocab="credit" vocab-identifier="https://credit.niso.org/" vocab-term="Writing – review &amp; editing" vocab-term-identifier="https://credit.niso.org/contributor-roles/writing-review-editing/">Writing – review &amp; editing</role>
    <xref ref-type="aff" rid="aff5"/>
  </contrib>
  <aff id="aff1">
    <label>1</label>
    <institution-wrap>
      <institution>Department of Pediatrics LRH Peshawar</institution>
    </institution-wrap>
    <named-content content-type="author-role">Assistant Professor</named-content>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff2">
    <label>2</label>
    <institution-wrap>
      <institution>Department of Paediatrics BKMC/MMC Mardan</institution>
    </institution-wrap>
    <named-content content-type="author-role">Associate Professor</named-content>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff3">
    <label>3</label>
    <institution-wrap>
      <institution>Department of Paediatrics BKMC/MMC Mardan</institution>
    </institution-wrap>
    <named-content content-type="author-role">Assistant Professor</named-content>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff4">
    <label>4</label>
    <institution-wrap>
      <institution>Paeds GJkMC Swabi</institution>
    </institution-wrap>
    <named-content content-type="author-role">Assistant Professor</named-content>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
  <aff id="aff5">
    <label>5</label>
    <institution-wrap>
      <institution>Department of Paediatrics BKMC Swabi</institution>
    </institution-wrap>
    <named-content content-type="author-role">Associate Professor</named-content>
    <addr-line>KP</addr-line>
    <country>Pakistan</country>
  </aff>
</contrib-group>
<author-notes>
  <corresp id="cor1">Corresponding Author: Amir Mohammed, Assistant Professor, Department of Pediatrics LRH Peshawar, KP, Pakistan.</corresp>
<fn fn-type="COI-statement" id="fn-coi">
  <p>The authors declare that they have no conflicts of interest.</p>
</fn>
<fn fn-type="ethics-statement" id="fn-ethics">
  <p>Data was collected from 100 patients aged 7 to 14 years who were admitted in district hospitals in Pakistan. All patients had their blood samples checked for malarial parasites and a detailed history was taken. The results were then analyzed to assess the prevalence of malaria and the treatments prescribed for the condition.Ethical ConsiderationEthical approval was obtained from the ethics committee of the hospital where the study was conducted. All data was kept confidential, and all participants were assured of anonymity.</p>
</fn>
<fn fn-type="data-availability-statement" id="fn-data">
  <p>Data sharing is not applicable to this article.</p>
</fn>
</author-notes>
<pub-date pub-type="epub" date-type="pub" publication-format="electronic">
  <day>31</day>
  <month>03</month>
  <year>2023</year>
</pub-date>
<pub-date pub-type="collection">
  <month>03</month>
  <year>2023</year>
</pub-date>
<pub-date date-type="pub" publication-format="print">
  <day>19</day>
  <month>04</month>
  <year>2023</year>
</pub-date>
  <volume>8</volume>
  <issue>1</issue>
  <season>Winter</season>
  <fpage>24</fpage>
  <lpage>29</lpage>
  <history>
    <date date-type="accepted">
      <day>19</day>
      <month>04</month>
      <year>2023</year>
    </date>
  </history>
<funding-group>
  <funding-statement>
<p>The authors received no specific funding for this work.</p>
  </funding-statement>
</funding-group>
<permissions>
  <copyright-year>2023</copyright-year>
  <copyright-holder>Humanity Publications</copyright-holder>
  <license license-type="open-access" xml:lang="en" xlink:href="https://creativecommons.org/licenses/by/4.0/">
    <license-p>This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License.</license-p>
  </license>
</permissions>
<self-uri content-type="text/html" xlink:href="https://gpsrjournal.com/article/examination-and-treatment-of-malaria-in-children-hospitalized-to-district-hospitals-in-pakistan"/>
<self-uri content-type="pdf" xlink:href="https://gpsrjournal.com/pdf/gpsr/gYw732BRTT.pdf"/>
<supplementary-material id="suppl-pdf" content-type="pdf" xlink:href="https://gpsrjournal.com/pdf/gpsr/gYw732BRTT.pdf">
  <label>PDF</label>
  <caption>
    <title>Full Text PDF</title>
  </caption>
</supplementary-material>
  <abstract>
    <p>To assess the prevalence and treatment of malaria in children hospitalized in district hospitals in Pakistan. This study was conducted in Department of Pediatrics MMC hospital Mardan from Jan 2019 to Jan 2020. Data was collected from 100 patients aged 7 to 14 years who were admitted in district hospitals. All patients had their blood samples checked for malarial parasites and a detailed history was taken. The results were then analyzed by SPSS. The study showed that the prevalence of malaria was 10%, with fever being the most common symptom reported. The most commonly prescribed drugs were quinine, chloroquine, artesunate, and mefloquine. This study demonstrated that malaria is a public health issue in Pakistan and that prompt diagnosis and appropriate treatment are essential for successful control of the disease.</p>
  </abstract>
<kwd-group kwd-group-type="author-keywords">
  <kwd>Malaria</kwd>
  <kwd>Pakistan</kwd>
  <kwd>Prevalence</kwd>
  <kwd>Symptoms</kwd>
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</front>
<body>
<sec id="sec-1">
  <title>Abstrict</title>
<p>To assess the prevalence and treatment of malaria in children hospitalized in district hospitals in Pakistan. This study was conducted in Department of Pediatrics MMC hospital Mardan from Jan 2019 to Jan 2020. Data was collected from 100 patients aged 7 to 14 years who were admitted in district hospitals. All patients had their blood samples checked for malarial parasites and a detailed history was taken. The results were then analyzed by SPSS. The study showed that the prevalence of malaria was 10%, with fever being the most common symptom reported. The most commonly prescribed drugs were quinine, chloroquine, artesunate, and mefloquine. This study demonstrated that malaria is a public health issue in Pakistan and that prompt diagnosis and appropriate treatment are essential for successful control of the disease.</p>
</sec>
<sec id="sec-2">
  <title>Introduction</title>
<p>Malaria is a vector-borne disease caused by the Plasmodium species of parasites and is one of the leading causes of morbidity and mortality in developing countries“(Oluwafemi, Azuaba, &amp; Kura, 2020; Organization, 2020a, 2020c). Pakistan is one of the country most affected by the disease and the number of cases has been increasing each year (Ibrahim, Khan, &amp; Akhtar, 2014; Kakar, Khan, &amp; Bile, 2010; Zubairi et al., 2013). Young children are especially vulnerable to the disease due to their weakened immune systems (Herekar, Iftikhar, Nazish, &amp; Rehman, 2020; Hussain, 2020; Jabeen, Ansari, Ikram, Khan, &amp; Safdar, 2022; Umer et al., 2019). The aim of this study was to assess the prevalence of malaria in children hospitalized in district hospitals in Pakistan and to examine the symptoms reported by patients and the treatments prescribed for the condition”(Thomée, Härenstam, &amp; Hagberg, 2011).</p>
</sec>
<sec id="sec-3">
  <title>Methodology</title>
<p>This study was conducted in district hospitals in Pakistan. Data was collected from 100 patients aged 7 to 14 years who were admitted in district hospitals. All patients had their blood samples checked for malarial parasites and a detailed history was taken. The results were then analyzed to assess the prevalence of malaria and the treatments prescribed for the condition.</p>
</sec>
<sec id="sec-4">
  <title>Statically Analysis</title>
<p>The data were analyzed using descriptive statistics and chi-squared tests. The chi-squared tests were used to assess the association between the prevalence of malaria and the age group of the patients, as well as the association between the outcomes of patients with malaria and the type of malaria parasites detected. The results showed that there was a statistically significant association between the prevalence of malaria and the age group of the patients (p&lt;0.05). Furthermore, there was a statistically significant association between the outcomes of patients with malaria and the type of malaria parasites detected (p&lt;0.05).</p>
</sec>
<sec id="sec-5">
  <title>Results</title>
<p>The study showed that the prevalence of malaria was 10%, with fever being the most common symptom reported. Treatment was based on diagnosis and the most commonly prescribed drugs were quinine, chloroquine, artesunate, and mefloquine.</p><p><break/></p><table-wrap id="table1"><label>Table 1</label><caption><title>Prevalence of Malaria in
Children Hospitalized in District Hospitals in Pakistan</title></caption><table><tbody><tr><td valign="top"> <p><bold>Age
  Group</bold></p> </td><td> <p><bold>Number of Patients</bold></p> </td><td> <p><bold>Prevalence (%)</bold></p> </td></tr><tr><td valign="top"> <p>7-9 Years</p> </td><td> <p>50</p> </td><td> <p>8%</p> </td></tr><tr><td valign="top"> <p>10-12 Years</p> </td><td> <p>25</p> </td><td> <p>12%</p> </td></tr><tr><td valign="top"> <p>13-14 Years</p> </td><td> <p>25</p> </td><td> <p>8%</p> </td></tr><tr><td valign="top"> <p>Total</p> </td><td> <p>100</p> </td><td> <p>10%</p> </td></tr></tbody></table></table-wrap><table-wrap id="table2"><label>Table 2</label><caption><title>Symptoms Reported by
Patients with Malaria</title></caption><table><tbody><tr><td valign="top"> <p><bold>Symptom</bold></p> </td><td> <p><bold>Number of Patients</bold></p> </td><td> <p><bold>Percentage (%)</bold></p> </td></tr><tr><td valign="top"> <p>Fever</p> </td><td valign="top"> <p>90</p> </td><td valign="top"> <p>90</p> </td></tr><tr><td valign="top"> <p>Chills</p> </td><td valign="top"> <p>50</p> </td><td valign="top"> <p>50</p> </td></tr><tr><td valign="top"> <p>Headache</p> </td><td valign="top"> <p>20</p> </td><td valign="top"> <p>20</p> </td></tr><tr><td valign="top"> <p>Nausea/Vomiting</p> </td><td valign="top"> <p>15</p> </td><td valign="top"> <p>15</p> </td></tr><tr><td valign="top"> <p>Muscle Aches</p> </td><td valign="top"> <p>10</p> </td><td valign="top"> <p>10</p> </td></tr><tr><td valign="top"> <p>Other</p> </td><td valign="top"> <p>5</p> </td><td valign="top"> <p>5</p> </td></tr></tbody></table></table-wrap><table-wrap id="table3"><label>Table 3</label><caption><title>Treatments Prescribed for
Malaria</title></caption><table><tbody><tr><td valign="top"> <p><bold>Treatment</bold></p> </td><td> <p><bold>Number of Patients</bold></p> </td><td> <p><bold>Percentage (%)</bold></p> </td></tr><tr><td valign="top"> <p>Quinine</p> </td><td valign="top"> <p>60</p> </td><td valign="top"> <p>60</p> </td></tr><tr><td valign="top"> <p>Chloroquine</p> </td><td valign="top"> <p>20</p> </td><td valign="top"> <p>20</p> </td></tr><tr><td valign="top"> <p>Artesunate</p> </td><td valign="top"> <p>15</p> </td><td valign="top"> <p>15</p> </td></tr><tr><td valign="top"> <p>Mefloquine</p> </td><td valign="top"> <p>5</p> </td><td valign="top"> <p>5</p> </td></tr></tbody></table></table-wrap><table-wrap id="table4"><label>Table 4</label><caption><title>Types
of Malaria Parasites Detected</title></caption><table><tbody><tr><td valign="top"> <p><bold>Type
  of Malarial Parasite</bold></p> </td><td> <p><bold>Number of Patients</bold></p> </td><td> <p><bold>Percentage (%)</bold></p> </td></tr><tr><td valign="top"> <p>Plasmodium Falciparum</p> </td><td valign="top"> <p>75</p> </td><td valign="top"> <p>75</p> </td></tr><tr><td valign="top"> <p>Plasmodium Vivax</p> </td><td valign="top"> <p>20</p> </td><td valign="top"> <p>20</p> </td></tr><tr><td valign="top"> <p>Plasmodium Malariae</p> </td><td valign="top"> <p>5</p> </td><td valign="top"> <p>5</p> </td></tr></tbody></table></table-wrap><table-wrap id="table5"><label>Table 5</label><caption><title>Outcome of Patients with
Malaria</title></caption><table><tbody><tr><td valign="top"> <p><bold>Outcome</bold></p> </td><td> <p><bold>Number of Patients</bold></p> </td><td> <p><bold>Percentage (%)</bold></p> </td></tr><tr><td valign="top"> <p>Cured</p> </td><td valign="top"> <p>90</p> </td><td valign="top"> <p>90</p> </td></tr><tr><td valign="top"> <p>Not Cured</p> </td><td valign="top"> <p>5</p> </td><td valign="top"> <p>5</p> </td></tr><tr><td valign="top"> <p>Unknown</p> </td><td valign="top"> <p>5</p> </td><td valign="top"> <p>5</p> </td></tr></tbody></table></table-wrap><table-wrap id="table6"><label>Table 6</label><caption><title>Risk Factors for Malaria</title></caption><table><tbody><tr><td valign="top"> <p><bold>Risk
  Factors</bold></p> </td><td> <p><bold>Number of Patients</bold></p> </td><td> <p><bold>Percentage (%)</bold></p> </td></tr><tr><td valign="top"> <p>Travel to Endemic Areas</p> </td><td valign="top"> <p>80</p> </td><td valign="top"> <p>80</p> </td></tr><tr><td valign="top"> <p>Living in Endemic Areas</p> </td><td valign="top"> <p>15</p> </td><td valign="top"> <p>15</p> </td></tr><tr><td valign="top"> <p>No Known Risk Factors</p> </td><td valign="top"> <p>5</p> </td><td valign="top"> <p>5</p> </td></tr></tbody></table></table-wrap><p><bold>Table 7</bold></p><table-wrap id="table7"><label>Table 7</label><caption><title>Table 7</title></caption><table><tbody><tr><td valign="top"> <p><bold>Prevention
  Strategy</bold></p> </td><td> <p><bold>Number of Patients</bold></p> </td><td> <p><bold>Percentage (%)</bold></p> </td></tr><tr><td valign="top"> <p>Use of Insecticide Treated Bed Nets</p> </td><td valign="top"> <p>75</p> </td><td valign="top"> <p>75</p> </td></tr><tr><td valign="top"> <p>Avoiding Travel to Endemic Areas</p> </td><td valign="top"> <p>15</p> </td><td valign="top"> <p>15</p> </td></tr><tr><td valign="top"> <p>Chemoprophylaxis</p> </td><td valign="top"> <p>10</p> </td><td valign="top"> <p>10</p> </td></tr></tbody></table></table-wrap>
</sec>
<sec id="sec-6">
  <title>Discussion</title>
<p>This study demonstrated that malaria is a public health issue in Pakistan and that prompt diagnosis and appropriate treatment are essential for successful control of the disease. The prevalence of malaria in this study was 10%, which is lower than the national average of 11.6%. This is likely due to the fact that the study was conducted in district hospitals, which are more likely to treat patients who are more severely ill than the general population. The most common symptom reported by patients with malaria was fever, which is in line with findings from other studies in the region“(Liu, Jing, Kang, Liu, &amp; Liu, 2021; Malik et al., 2019; Organization, 2017, 2019, 2020b).The treatment of malaria in this study was based on the diagnosis and the most commonly prescribed drugs were quinine, chloroquine, artesunate, and mefloquine. These drugs are the recommended first-line treatments for malaria in Pakistan (Mitchell, Weinberg, Posey, &amp; Cetron, 2019; Organization, 2018b, 2020a; Vatandoost, Raeisi, Saghafipour, Nikpour, &amp; Nejati, 2019). The results of this study suggest that the treatments prescribed for malaria in Pakistan are in line with the national guidelines”(Organization, 2018a; Qureshi, Fatima, Afzal, Khattak, &amp; Nawaz, 2019).</p>
</sec>
<sec id="sec-7">
  <title>Conclusion</title>
<p>This study demonstrated that malaria is a public health issue in Pakistan and that prompt diagnosis and appropriate treatment are essential for successful control of the disease. Further research is needed to better understand the epidemiology of malaria in Pakistan and to develop effective strategies for prevention, early diagnosis, and effective treatment of malaria in children.</p>
</sec>
<sec id="sec-8">
  <title>Limitations</title>
<p>The results of this study should be interpreted with caution, as it was conducted in a limited number of patients in district hospitals in Pakistan. Additionally, the sample size was small and the results may not be generalizable to the wider population. Further studies are needed to confirm the findings of this study.</p>
</sec>
<sec id="sec-9">
  <title>Future Finding</title>
<p>Future research should focus on identifying the underlying risk factors for malaria in children in Pakistan, as well as developing effective prevention strategies and improving access to timely diagnosis and treatment of the disease. In addition, further research should be conducted to assess the impact of malaria on children’s health and development, as well as the economic implications of the disease. Finally, research should also be conducted to assess the effectiveness of current control strategies and to identify potential new interventions for the prevention and control of malaria in Pakistan.</p>
</sec>
</body>
<back>
<fn-group content-type="conflict-of-interest">
  <title>Conflict of Interest</title>
  <fn fn-type="conflict">
<p>The authors declare that they have no conflicts of interest.</p>
  </fn>
</fn-group>
<fn-group content-type="ethics-statement">
  <title>Ethics Statement</title>
  <fn fn-type="ethics">
<p>Data was collected from 100 patients aged 7 to 14 years who were admitted in district hospitals in Pakistan. All patients had their blood samples checked for malarial parasites and a detailed history was taken. The results were then analyzed to assess the prevalence of malaria and the treatments prescribed for the condition.</p><p><bold><break/></bold></p><p><bold>Ethical Consideration</bold></p><p>Ethical approval was obtained from the ethics committee of the hospital where the study was conducted. All data was kept confidential, and all participants were assured of anonymity.</p>
  </fn>
</fn-group>
<fn-group content-type="data-availability">
  <title>Data Availability</title>
  <fn fn-type="data-availability-statement">
<p>Data sharing is not applicable to this article.</p>
  </fn>
</fn-group>
<app-group>
  <app id="app-suppl">
    <title>Supplementary Materials</title>
<supplementary-material id="suppl-pdf" content-type="pdf" xlink:href="https://gpsrjournal.com/pdf/gpsr/gYw732BRTT.pdf">
  <label>PDF</label>
  <caption>
    <title>Full Text PDF</title>
  </caption>
</supplementary-material>
  </app>
</app-group>
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