http://dx.doi.org/10.31703/gpsr.2023(VIII-III).04
10.31703/gpsr.2023(VIII-III).04
Published : Sep 2023
Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study
Transdermal delivery systems which are directly applied on the skin serve as a substitute for oral drug delivery avoiding first-pass metabolism. The problem of drug penetration through the skin definitely remains one of the biggest issues. This study ascertains the likelihood of DMSO, a penetration enhancer to boost KT, one of the most powerful analgesics. Through DMSO amount variations on KT were prepared and then permeation was studied by means of a Franz Diffusion cell system on rat skin. It increased the permeability coefficient and flux with the increase of the DMSO level, and it reached the maximum when the DMSO concentration was 0. 1. Further understanding of mechanisms and optimal DMSO concentrations seem to be necessary for future development of this promising anticancer treatment approach. Briefly summarizing, DMSO does seem to meet the demands, according to the transdermal drug delivery efficacy standpoint, being safe and convenient for topical application.
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ransdermal drug delivery, Dimethyl Sulfoxide, Ketorolac Tromethamine, Franz Diffusion Cell, Permeability
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(1) Farhan Mukhtar
MPhil, Department of Pharmaceutics, The Islamia University of Bahawalpur, Punjab, Pakistan.
(2) Muhammad Shoaib Khan
Professor, Department of Pharmaceutics, The Islamia University of Bahawalpur, Punjab, Pakistan.
(3) Hafiz Muhammad Usman Abid
MPhil, Department of Pharmaceutics, The Islamia University of Bahawalpur, Punjab, Pakistan.
(4) Asif Usman Ali
MPhil, Department of Pharmaceutics, The Islamia University of Bahawalpur, Punjab, Pakistan.
(5) Asad Usman Ali
MPhil, Department of Pharmaceutics, The Islamia University of Bahawalpur, Punjab, Pakistan.
(6) Waqar Usman Mukhtar
MPhil, Department of Pharmaceutics, The Islamia University of Bahawalpur, Punjab, Pakistan.
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Cite this article
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APA : Mukhtar, F., Khan, M. S., & Abid, H. M. U. (2023). Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study. Global Pharmaceutical Sciences Review, VIII(III), 33-38. https://doi.org/10.31703/gpsr.2023(VIII-III).04
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CHICAGO : Mukhtar, Farhan, Muhammad Shoaib Khan, and Hafiz Muhammad Usman Abid. 2023. "Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study." Global Pharmaceutical Sciences Review, VIII (III): 33-38 doi: 10.31703/gpsr.2023(VIII-III).04
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HARVARD : MUKHTAR, F., KHAN, M. S. & ABID, H. M. U. 2023. Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study. Global Pharmaceutical Sciences Review, VIII, 33-38.
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MHRA : Mukhtar, Farhan, Muhammad Shoaib Khan, and Hafiz Muhammad Usman Abid. 2023. "Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study." Global Pharmaceutical Sciences Review, VIII: 33-38
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MLA : Mukhtar, Farhan, Muhammad Shoaib Khan, and Hafiz Muhammad Usman Abid. "Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study." Global Pharmaceutical Sciences Review, VIII.III (2023): 33-38 Print.
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OXFORD : Mukhtar, Farhan, Khan, Muhammad Shoaib, and Abid, Hafiz Muhammad Usman (2023), "Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study", Global Pharmaceutical Sciences Review, VIII (III), 33-38
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TURABIAN : Mukhtar, Farhan, Muhammad Shoaib Khan, and Hafiz Muhammad Usman Abid. "Enhancing Transdermal Delivery of Ketorolac Tromethamine Using Dimethyl Sulfoxide: A Systematic Study." Global Pharmaceutical Sciences Review VIII, no. III (2023): 33-38. https://doi.org/10.31703/gpsr.2023(VIII-III).04